Peer-Reviewed Original Research
(*: graduate student advisor publication, _: corresponding author)
1. *M. Özkılınç Önen, E. Everest, T. Demirci, P. Köprülü Şen, E. Kızıltepe Kısakesen, Y. Özgüler, S.N. Esatoğlu, E. Seyahi, E. Tahir Turanlı. HLA-B gene methylation and expression in Behçet’s syndrome: a potential role of epigenetics in the pathogenesis. Clinical and Experimental Rheumatology, December 2024 (in print).
2. Tatli O, Oz Y, Dingiloglu B, Yalcinkaya D, Basturk E, Korkmaz M, Akbulut L, Hatipoglu D, Kirmacoglu C, Akgun B, Turk K, Pinar O, Sariyar Akbulut B, Atabay Z, Tahir Turanli E, Kazan D, Dinler Doganay G. A two-step purification platform for efficient removal of Fab-related impurities: A case study for Ranibizumab. Heliyon. 2023 Oct 31;9(11):e21001. doi: 10.1016/j.heliyon.2023.e21001. PMID: 38027967; PMCID: PMC10651443.
3. *Everest E, Uygunoglu U, Tutuncu M, Bulbul A, Onat UI, Unal M, Avsar T, Saip S, Bilge U, Turanli ET, Siva A. Prospective outcome analysis of multiple sclerosis cases reveals candidate prognostic cerebrospinal fluid markers. PLoS One. 2023 Jun 20;18(6):e0287463. doi: 10.1371/journal.pone.0287463. PMID: 37339131; PMCID: PMC10281571.
4. Merve Ö. Özkılınç*, Umut İ. Onat, Serdal Uğurlu, Ahmet C. Timuçin, Devrim Ö. Arslan, Elif Everest, Huri Özdoğan, Eda T. Turanlı. Detection of a rare variant in PSTPIP1 through three generations in a family with an initial diagnosis of FMF/MKD-overlapping phenotype. Rheumatology, 2023, kead044, https://doi.org/10.1093/rheumatology/kead044
5. *Everest, E., Ahangari, M., Uygunoglu, U., Tutuncu, M., Bulbul, A., Saip, S., Duman, T., Sezerman, U., Reich, D. S., Riley, B. P., Siva, A., & Tahir Turanli, E. (2022). Investigating the role of common and rare variants in multiplex multiple sclerosis families reveals an increased burden of common risk variation. Scientific reports, 12(1), 16984. https://doi.org/10.1038/s41598-022-21484-x
6. *Calis, S., Dogan, B., Durdagi, S., Celebi, A., Yapicier, O., Kilic, T., Turanli, E. T., & Avsar, T. (2022). A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo Glioblastoma tumor growth. Cell death discovery, 8(1), 433. https://doi.org/10.1038/s41420-022-01225-9
7. Ahangari, M., Everest, E., Nguyen, T. H., Verrelli, B. C., Webb, B. T., Bacanu, S. A., Tahir Turanli, E., & Riley, B. P. (2022). Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects. Brain, behavior, and immunity, 104, 183–190. https://doi.org/10.1016/j.bbi.2022.06.007
8. Inci, N., Akyildiz, E. O., Bulbul, A. A., Turanli, E. T., Akgun, E., Baykal, A. T., Colak, F., & Bozaykut, P. (2022). Transcriptomics and Proteomics Analyses Reveal JAK Signaling and Inflammatory Phenotypes during Cellular Senescence in Blind Mole Rats: The Reflections of Superior Biology. Biology, 11(9), 1253. https://doi.org/10.3390/biology11091253
9. Avşar, T., Çelikyapi Erdem, G., Terzioğlu, G., & Tahir Turanli, E. (2021). Investigation of neuro-inflammatory parameters in a cuprizone induced mouse model of multiple sclerosis. Turkish journal of biology, 45(5), 644–655. https://doi.org/10.3906/biy-2104-88
10. *Everest, E., Ülgen, E., Uygunoglu, U., Tutuncu, M., Saip, S., Sezerman, O. U.,& Turanli Tahir, E. (2021). Investigation of multiple sclerosis-related pathways through the integration of genomic and proteomic data. PeerJ, 9, e11922.
11. Omarjee, O., Mathieu, A. L., Quiniou, G., Moreews, M., Ainouze, M., Frachette, C., Melki, I., Dumaine, C., Gerfaud-Valentin, M., Duquesne, A., Kallinich, T., Tahir Turanli, E., Malcus, C., Viel, S., Pescarmona, R., Georgin-Lavialle, S., Jamilloux, Y., Larbre, J. P., Sarrabay, G., Magnotti, F., Belot, A. (2021). LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages. The Journal of experimental medicine, 218(3), e20201006. https://doi.org/10.1084/jem.20201006
12. *Kirectepe Aydin, A., Özgüler, Y., Uçar, D., Kasap, M., Akpınar, G., Seyahi, E., & Tahir Turanli, E. (2020). Peripheral blood mononuclear cell proteome profile in Behçet’s syndrome. Rheumatology International, 40(1), 65-74.
13. Ayata, N., Sezer, A. D., Bucak, S., & Turanlı, E. T. (2020). Preparation and in vitro characterization of monoclonal antibody ranibizumab conjugated magnetic nanoparticles for ocular drug delivery. Brazilian Journal of Pharmaceutical Sciences, 56.
14. *Karacan, İ., Balamir, A., Uğurlu, S., Aydın, A. K., Everest, E., Zor, S., ... & Turanlı, E. T. (2019). Diagnostic utility of a targeted next-generation sequencing gene panel in the clinical suspicion of systemic autoinflammatory diseases: a multi-center study. Rheumatology international, 39(5), 911-919.
15. Kilic, H., Sahin, S., Duman, C., Adrovic, A., Barut, K., Turanli, E. T., ... & Saltik, S. (2019). Spectrum of the neurologic manifestations in childhood-onset cryopyrin-associated periodic syndrome. European Journal of Paediatric Neurology, 23(3), 466-472.
16. *Karacan, İ., Diz Küçükkaya, R., Karakuş, F. N., Solakoğlu, S., Tolun, A., Hançer, V. S., & Turanlı, E. T. (2019). A Novel ATP6V0A2 Mutation Causing Recessive Cutis Laxa with Unusual Manifestations of Bleeding Diathesis and Defective Wound Healing. Turkish journal of haematology : official journal of Turkish Society of Haematology, 36(1), 29–36. https://doi.org/10.4274/tjh.galenos.2018.2018.0325
17. Olt, S., Öznas, O., Bağış, H., & Turanlı, E. T. (2019). Chemerin rs17173608 Gene Polymorphism is not Associated with Type 2 Diabetes Mellitus: A Cross-sectional Study. Folia medica, 61(1), 69-75.
18. Sahin, S., Adrovic, A., Barut, K. Turanlı, E. T. et al. Clinical, imaging and genotypical features of three deceased and five surviving cases with ADA2 deficiency. Rheumatol Int 38, 129–136 (2018). https://doi.org/10.1007/s00296-017-3740-3
19. Barut, K., Sahin, S., Adrovic, A., Sinoplu, A. B., Yucel, G., Pamuk, G., Aydın, A. K., Dasdemir, S., Turanlı, E. T., Buyru, N., & Kasapcopur, O. (2018). Familial Mediterranean fever in childhood: a single-center experience. Rheumatology international, 38(1), 67–74. https://doi.org/10.1007/s00296-017-3796-0
20. *Karacan, İ., Uğurlu, S., Tolun, A., Tahir Turanlı, E., & Ozdogan, H. (2017). Other autoinflammatory disease genes in an FMF-prevalent population: a homozygous MVK mutation and a novel heterozygous TNFRSF1A mutation in two different Turkish families with clinical FMF. Clinical and experimental rheumatology, 35 Suppl 108(6), 75–81.
21. *Erdem GC, Erdemir S, Abaci I, Aydin AKK, Everest E, Turanli ET. Alternatively spliced MEFV transcript lacking exon 2 and its protein isoform pyrin-2d implies an epigenetic regulation of the gene in inflammatory cell culture models. Genet Mol Biol. 2017 Jul-Sep;40(3):688-697. doi: 10.1590/1678-4685-GMB-2016-0234. Epub 2017 Aug 31. PMID: 28863210; PMCID: PMC5596369
22. *Avsar T, Durası İM, Uygunoğlu U, Tütüncü M, Demirci NO, Saip S, Sezerman OU, Siva A, Tahir Turanlı E. CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes. PLoS One. 2015 May 5;10(5):e0122045. doi: 10.1371/journal.pone.0122045. PMID: 25942430; PMCID: PMC4420287.
23. *Avsar T, Korkmaz D, Tütüncü M, Demirci NO, Saip S, Kamasak M, Siva A, Turanli ET. Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis. Mult Scler. 2012 Aug;18(8):1081-91. doi: 10.1177/1352458511433303. Epub 2012 Jan 17. PMID: 22252467.
24. *Kirectepe AK, Erdem GC, Senturk N, Arisoy N, Hatemi G, Ozdogan H, Kasapcopur O, Tahir Turanli E. Increased expression of exon 2 deleted MEFV transcript in familial Mediterranean fever patients. Int J Immunogenet. 2011 Aug;38(4):327-9. doi: 10.1111/j.1744-313X.2011.01015.x. Epub 2011 May 25. PMID: 21615705.
25. *Kirectepe AK, Kasapcopur O, Arisoy N, Celikyapi Erdem G, Hatemi G, Ozdogan H, Tahir Turanli E. Analysis of MEFV exon methylation and expression patterns in familial Mediterranean fever. BMC Med Genet. 2011 Aug 7;12:105. doi: 10.1186/1471-2350-12-105. PMID: 21819621; PMCID: PMC3175150.
26. Seyahi E, Tahir Turanli E, Mangan MS, Celikyapi G, Oktay V, Cevirgen D, Kuzuoglu D, Ozoglu S, Yazici H. The prevalence of Behçet's syndrome, familial Mediterranean fever, HLA-B51 and MEFV gene mutations among ethnic Armenians living in Istanbul, Turkey. Clin Exp Rheumatol. 2010 Jul-Aug;28(4 Suppl 60):S67-75. Epub 2010 Sep 24. PMID: 20868574.
27. Masatlioglu S, Seyahi E, Tahir Turanli E, Fresko I, Gogus F, Senates E, Oguz Savran F, Yazici H. A twin study in Behçet's syndrome. Clin Exp Rheumatol. 2010 Jul-Aug;28(4 Suppl 60):S62-6. Epub 2010 Sep 24. PMID: 20868573.
28. Turanli ET, Beger T, Erdincler D, Curgunlu A, Karaman S, Karaca E, Dasdemir S, Bolayirli M, Yazici H. Common MEFV mutations and polymorphisms in an elderly population: an association with E148Q polymorphism and rheumatoid factor levels. Clin Exp Rheumatol. 2009 Mar-Apr;27(2):340-3. PMID: 19473580.
29. Bagis H, Arat S, Mercan HO, Aktoprakligil D, Caner M, Turanli ET, Baysal K, Turgut G, Sekmen S, Cirakoglu B. Stable transmission and expression of the hepatitis B virus total genome in hybrid transgenic mice until F10 generation. J Exp Zool A Comp Exp Biol. 2006 May 1;305(5):420-7. doi: 10.1002/jez.a.277. PMID: 16489557.
30. Ozbay F, Wigg KG, Turanli ET, Asherson P, Yazgan Y, Sandor P, Barr CL. Analysis of the dopamine beta hydroxylase gene in Gilles de la Tourette syndrome. Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141B(6):673-7. doi: 10.1002/ajmg.b.30393. PMID: 16838359.
31. Lowe N, Kirley A, Hawi Z, Sham P, Wickham H, Kratochvil CJ, Smith SD, Lee SY, Levy F, Kent L, Middle F, Rohde LA, Roman T, Tahir E, Yazgan Y, Asherson P, Mill J, Thapar A, Payton A, Todd RD, Stephens T, Ebstein RP, Manor I, Barr CL, Wigg KG, Sinke RJ, Buitelaar JK, Smalley SL, Nelson SF, Biederman J, Faraone SV, Gill M. Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. Am J Hum Genet. 2004 Feb;74(2):348-56. doi: 10.1086/381561. Epub 2004 Jan 19. PMID: 14732906; PMCID: PMC1181932.
32. D'Souza UM, Russ C, Tahir E, Mill J, McGuffin P, Asherson PJ, Craig IW. Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene. Biol Psychiatry. 2004 Nov 1;56(9):691-7. doi: 10.1016/j.biopsych.2004.08.008. PMID: 15522254.
33. Eley TC, Tahir E, Angleitner A, Harriss K, McClay J, Plomin R, Riemann R, Spinath F, Craig I. Association analysis of MAOA and COMT with neuroticism assessed by peers. Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):90-6. doi: 10.1002/ajmg.b.20046. PMID: 12815746.
34. Xu C, Ozbay F, Wigg K, Shulman R, Tahir E, Yazgan Y, Sandor P, Barr CL; Tourette Syndrome Association Genetic Consortium. Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome. Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):54-9. doi: 10.1002/ajmg.b.20001. PMID: 12707939.
35. Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, Ozbay F, Yazgan Y, Simonoff E, Thompson M, Taylor E, Asherson P. Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry. 2001 Jul;6(4):425-8. doi: 10.1038/sj.mp.4000914. PMID: 11443527.
36. Tahir E, Yazgan Y, Cirakoglu B, Ozbay F, Waldman I, Asherson PJ. Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children. Mol Psychiatry. 2000 Jul;5(4):396-404. doi: 10.1038/sj.mp.4000744. PMID: 10889550.
37. Tahir E, Curran S, Yazgan Y, Ozbay F, Cirakoglu B, Asherson PJ. No association between low- and high-activity catecholamine-methyl-transferase (COMT) and attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children. Am J Med Genet. 2000 Jun 12;96(3):285-8. doi: 10.1002/1096-8628(20000612)96:3<285::aid-ajmg10>3.0.co;2-d. PMID: 10898901.
38. Riley BP, Tahir E, Rajagopalan S, Mogudi-Carter M, Fauré S, Weissenbach J, Jenkins T, Williamson R. A linkage study of the N-methyl-D-aspartate receptor subunit gene loci and schizophrenia in southern African Bantu-speaking families. Psychiatr Genet. 1997 Summer;7(2):57-74. doi: 10.1097/00041444-199722000-00002. PMID: 9285963.
Reviews
39. Inci, N., Kamali, D., Akyildiz, E. O., Tahir Turanli, E., & Bozaykut, P. (2022). Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models. Frontiers in aging, 3, 828058. https://doi.org/10.3389/fragi.2022.828058
40. Duman, N., ALzaidi, Z., Aynekin, B., Taskin, D., Demirors, B., Yildirim, A., Sahin, I. O., Bilgili, F., Turanli, E. T., Beccari, T., Bertelli, M., & Dundar, M. (2021). COVID-19 vaccine candidates and vaccine development platforms available worldwide. Journal of pharmaceutical analysis, 11(6), 675–682. https://doi.org/10.1016/j.jpha.2021.09.004
41. Precone,V.,Dundar,M.,Beccari,T.,Turanli,E.,Cecchin,S.,Marceddu,G.,Manara,E. & Bertelli,M.(2018).Quality assurance of genetic laboratories and the EBTNA practice certification, a simple standardization assurance system for a laboratory network. The EuroBiotech Journal,2(4) 215-222. https://doi.org/10.2478/ebtj-2018-0052
42. Turanlı, E. T., Everest, E., Balamir, A., Aydın, A. K., & Kasapçopur, Ö. (2017). Role of genetics in pediatric rheumatology. Turkish Archives of Pediatrics/Türk Pediatri Arşivi, 52(3), 113.
43. ADHD Molecular Genetics Network (E Ergelen). Collaborative possibilities for molecular genetic studies of attention deficit hyperactivity disorder: report from an international conference. Am J Med Genet. 2000 Jun 12;96(3):251-7. doi: 10.1002/1096-8628(20000612)96:3<251::aid-ajmg3>3.0.co;2-i. PMID: 10898894.
Case Reports, Technical Notes, Letters
44. Parlar K, Tahir Turanli E, Nuhoglu Kantarci E, Hacioglu A, Kirectepe Aydin A, Ayla AY, Voyvoda U, Ozdogan H, Ugurlu S. A case with febrile attacks and vasculopathy associated with ADA2 and MEFV pathogenic variants. Mod Rheumatol Case Rep. 2023 Aug 5:rxad045. doi: 10.1093/mrcr/rxad045. Epub ahead of print. PMID: 37542433.
45. Sahin, S., Adrovic, A., Barut, K., Baran, S., Tahir Turanli, E., Canpolat, N., ... & Kasapcopur, O. (2020). A 9.5-year-old boy with recurrent neurological manifestations and severe hypertension, treated initially for polyarteritis nodosa, was subsequently diagnosed with adenosine deaminase type 2 deficiency (DADA2) which responded to anti-TNF-α. Paediatrics and International Child Health, 40(1), 65-68.
46. Çakan, M., Aktay-Ayaz, N., Karadağ, Ş. G., Tahir-Turanlı, E., Stafstrom, K., Bainter, W., Geha, R. S., & Chou, J. (2019). Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2. The Turkish journal of pediatrics, 61(3), 413–417. https://doi.org/10.24953/turkjped.2019.03.014
47. Başaran, Ö., Uncu, N., Çakar, N., Turanlı, E. T., Kiremitci, S., Aydın, F., & Bayrakcı, U. S. (2018). C3 glomerulopathy in NLRP12-related autoinflammatory disorder: case-based review. Rheumatology International, 38(8), 1571-1576.
48. *Karacan, I., Uğurlu, S., Şahin, S., Everest, E., Kasapçopur, Ö., Tolun, A., ... & Turanli, E. T. (2018). LACC1 gene defects in familial form of juvenile arthritis. The Journal of Rheumatology, 45(5), 726-728.
Book Chapters
49. Tahir Turanlı E, Kireçtepe Aydın A, Özkılınç Önen M. Genetic and Epigenetic Research in Behcet’s Disease. Seyahi E. (ed). Behçet’s Disease (1st Edition). Ankara: Türkiye Klinikleri; (p.21-28 (Turkish)
50. Tahir Turanli E and Everest E (2016). Nanomedicine, in Low-dimentional and Nanostructured Materials and Devices, Ünlü H, Horing NJM, Dabowski J (editors) (Germany: Springer) ISBN: 978-3-319-25338-1
51. Turanli, E. T., Avsar, T., Uygunoğlu, U., Kantarci, O. H., & Siva, A. (2015). Biomarkers for phase switches in multiple sclerosis. In General Methods in Biomarker Research and their Applications.
52. Avşar T, Uygunoğlu U, Siva A and Tahir Turanlı E (2013). Importance of Biomarkers in diagnosis and prognosis of MS. Rana Karabudak (ed.) Basic and Clinical Neuroimmunology (chapter 34; 461-467), Ankara, ADA publications (Turkish)
