The study titled "Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure" which was conducted by Prof. Dr. Uğur ÖZBEK, Department of Medical Genetics and Assoc. Prof. Dr. Özden HATIRNAZ NG Department of Medical Biology was published in the December 2021 issue of the journal PLOS ONE. Ozden Hatirnaz Ng, Sezer Akyoney, Ilayda Sahin, Huseyin Okan Soykam, Gunseli Bayram Akcapinar, Ozkan Ozdemir, Derya Dilek Kancagi, Gozde Sir Karakus, Bulut Yurtsever, Ayse Sesin Kocagoz, Ercument Ovali, Ugur Ozbek shared the authorship. The study included the analysis of SARS-CoV-2 genome sequencing results, obtained from COVID-19 patients, which were observed in Turkey and accessible in the GISAID database until May 2021. The mutation screening and examination of the effects of these mutations on the Spike protein were analyzed.

For this purpose, a collective analysis of total 4607 viral genome sequences that were uploaded to GISAID database, by the Turkish Ministry of Health, academic institutions in Turkey and private health institutions was performed. The frequency of the variants and their incidence at certain time intervals were determined. SARS-CoV-2 subtypes separated by phylogenetic branching and the frequency of the variants across Turkey, Europe, Asia and the USA were compared. Additionally, 13 SARS-CoV-2 genomes obtained from patients treated at Acıbadem Healthcare Institutions and cultured in Acıbadem LabCell laboratories were sequenced with next-generation sequencing technologies, and their mutations were determined by bioinformatic analysis and the effects of these mutations on Spike protein were modeled with 3D simulation methods. This study provides important findings in terms of collective analysis of all viral genome data obtained in our country. The results show the importance of the sequencing in the discovery of new mutations, tracking viral spread, and advancing vaccination programs. Please click to read the paper.

Last Updated At: 20/12/2021
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